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CS-W001157 4
Total: USD 88.00

2,6-Dihydroxy-3-cyanopyridine

  • CAS No. 35441-10-2

  • Cat. No. CS-W005677
  • Molecule weight136.11
  • Purity≥97%
  • MDL No.MFCD11558977

*For research and further manufacturing use only, not for direct human use.

2,6-Dihydroxy-3-cyanopyridine|CS-W005677

Structure of 35441-10-2

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General Information

  • CAS No. 35441-10-2
  • Cat. No. CS-W005677
  • Purity ≥97%
  • MDL No. MFCD11558977
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂O₂
  • Molecular Weight 136.11
  • Synonym(s) 1,2-dihydro-6-hydroxy-2-oxo-3-Pyridinecarbonitrile
  • SMILES N#CC1=CC=C(O)NC1=O

Description

2,6-Dihydroxy-3-cyanopyridine features a pyridine core functionalized with two hydroxyl groups at the 2 and 6 positions and a cyano group at the 3 position. This arrangement imparts strong hydrogen-bonding capacity and electronic polarization, enabling its use as a building block in heterocyclic synthesis and coordination chemistry. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions.

Application

2,6-Dihydroxy-3-cyanopyridine serves as a versatile building block for pyridine-based heterocycles, enabling efficient access to functionalized scaffolds via nucleophilic substitution and cyclization reactions. The ortho-dihydroxy and cyano groups provide complementary reactivity for metal-catalyzed coupling, protecting group manipulation, and derivatization under mild conditions. Its bench-stable solid form facilitates handling and purification in synthetic workflows.

Synthesis

  • Route1
    • null|null
      107-91-5
    • null|null
      623-47-2
    • ~79%
    • In-stock
      2,6-Dihydroxy-3-cyanopyridine|CS-W005677
      35441-10-2

    References

    • Juenemann, Werner; Opgenorth, Hans-Juergen; Scheuermann, Horst Angewandte Chemie, 1980 , vol. 92, # 5 p. 390 - 391
  • Route2
    • In-stock
      1,3-Dimethyluracil|CS-W008343
      874-14-6
    • null|null
      107-91-5
    • ~94%
    • In-stock
      2,6-Dihydroxy-3-cyanopyridine|CS-W005677
      35441-10-2

    References

    • Hirota; Kitade; Senda; et al. Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 846 - 851

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.88
  • LogP   -0.04782
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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