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CS-W001157 4
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2-Methoxycyclopentan-1-one

  • CAS No. 35394-09-3

  • Cat. No. CS-0432948
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Methoxycyclopentan-1-one|CS-0432948

Structure of 35394-09-3

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General Information

  • CAS No. 35394-09-3
  • Cat. No. CS-0432948
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) 2-METHOXYCYCLOPENTANONE
  • SMILES O=C1CCCC1OC

Description

2-Methoxycyclopentan-1-one is a cyclic ketone featuring a methoxy group at the 2-position, offering enhanced solubility and stability in polar solvents. This structure facilitates efficient incorporation into synthetic intermediates for pharmaceuticals and agrochemicals, particularly where controlled reactivity and ring integrity are critical.

Application

2-Methoxycyclopentan-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted cyclopentane scaffolds. Its enolizable ketone functionality facilitates aldol reactions and conjugate additions, while the methoxy group provides orthogonal reactivity for selective transformations. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • 2-methoxycyclopent-2-en-1-one|CS-0857215
      22323-97-3
    • ~%
    • In-stock
      2-Methoxycyclopentan-1-one|CS-0432948
      35394-09-3

    References

    • Winkler, Christoph K.; Stueckler, Clemens; Mueller, Nicole J.; Pressnitz, Desiree; Faber, Kurt European Journal of Organic Chemistry, 2010 , # 33 p. 6354 - 6358
  • Route2
    • null|null
      110-00-9
    • null|null
      694-28-0
    • ~0%
    • In-stock
      2-Methoxycyclopentan-1-one|CS-0432948
      35394-09-3
    • null|null
      84525-43-9

    References

    • Froehlisch, Baldur; Joachimi, Roland Chemische Berichte, 1987 , vol. 120, p. 1951 - 1960
  • Route3
    • (1R,2R)-2-Methoxycyclopentanol|CS-0783243
      113625-72-2
    • ~%
    • In-stock
      2-Methoxycyclopentan-1-one|CS-0432948
      35394-09-3

    References

    • Das, Goutam; Thornton, Edward R. Journal of the American Chemical Society, 1993 , vol. 115, # 4 p. 1302 - 1312

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   0.7544
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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