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Methyl 2-(4-amino-3-hydroxyphenyl)acetate

  • CAS No. 353525-11-8

  • Cat. No. CS-0102083
  • Molecule weight181.19
  • Purity≥97%
  • MDL No.MFCD20694774

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(4-amino-3-hydroxyphenyl)acetate|CS-0102083

Structure of 353525-11-8

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General Information

  • CAS No. 353525-11-8
  • Cat. No. CS-0102083
  • Purity ≥97%
  • MDL No. MFCD20694774
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₃
  • Molecular Weight 181.19
  • Synonym(s) methyl (4-amino-3-hydroxyphenyl)acetate
  • SMILES O=C(CC1=CC=C(C(O)=C1)N)OC

Description

Methyl 2-(4-amino-3-hydroxyphenyl)acetate features a phenolic hydroxyl and primary amine group flanking a methylene linker, enabling direct conjugation in peptide synthesis. This bifunctional scaffold integrates readily into bioactive molecule frameworks, offering enhanced solubility and stability under standard bench conditions.

Application

Methyl 2-(4-amino-3-hydroxyphenyl)acetate serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The molecule features orthogonal functional groups—amine, phenolic hydroxyl, and ester—that enable selective derivatization in standard coupling, acylation, and cyclization reactions. Its bench-stable nature and compatibility with common protecting group strategies facilitate efficient route design in medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.6899
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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