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Structure of 353258-35-2
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8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid features a rigid heterocyclic core combining electron-withdrawing chlorine and trifluoromethyl groups, enhancing its metabolic stability and binding affinity. This carboxylic acid moiety enables direct conjugation or salt formation for improved solubility in biological assays. The molecule’s defined electronic profile supports its use in medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant scaffolds.
8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and catalytic research. Its fused imidazopyridine core exhibits enhanced metabolic stability and favorable pharmacokinetic properties. The carboxylic acid group enables direct derivatization via amide coupling or esterification, while the chloro and trifluoromethyl substituents provide orthogonal functional handles for cross-coupling reactions. This compound demonstrates excellent bench stability and compatibility with standard purification techniques, facilitating its use in high-throughput synthesis of bioactive molecules.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: