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CS-W001157 4
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4-(Azetidin-1-yl)benzaldehyde

  • CAS No. 353247-81-1

  • Cat. No. CS-0468694
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Azetidin-1-yl)benzaldehyde|CS-0468694

Structure of 353247-81-1

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General Information

  • CAS No. 353247-81-1
  • Cat. No. CS-0468694
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO
  • Molecular Weight 161.20
  • Synonym(s) 7-FLUOROPHTHALODINITRILE
  • SMILES O=CC1=CC=C(N2CCC2)C=C1

Description

4-(Azetidin-1-yl)benzaldehyde features a reactive aldehyde group flanked by an electron-rich azetidine ring, enabling direct conjugation in synthetic transformations. This bench-stable scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitor and fluorescent probe development.

Application

4-(Azetidin-1-yl)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically active scaffolds through facile imine formation and reductive amination. The aldehyde functionality reacts readily with amines under mild conditions, while the azetidine ring provides enhanced solubility and favorable pharmacokinetic properties. Its bench-stable nature and compatibility with common protecting group strategies facilitate straightforward purification and integration into complex molecular architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   1.7092
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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