2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine

Name: 2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 35265-82-8
Cat. No. CS-0052157
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine|CS-0052157

Structure of 35265-82-8

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General Information

CAS No. 35265-82-8
Cat. No. CS-0052157
Purity ≥98%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄Cl₂N₂S
Molecular Weight 219.09
Synonym(s) 2,4-Dichloro-6-Methylthieno[3,2-d]Pyrimidine2,4-DICHLORO-6-METHYLTHIENO[3,2-D]PYRIMIDINE
SMILES CC1=CC2=NC(Cl)=NC(Cl)=C2S1

Description

2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine features a fused thienopyrimidine core with strategically positioned chloro and methyl substituents, enabling selective reactivity in cross-coupling and heterocycle elaboration. This bench-stable scaffold integrates readily into bioactive molecule design, offering enhanced metabolic stability and favorable electronic properties for medicinal chemistry applications.

Application

2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of purine and thiophene-fused scaffolds. Its dichloro substitution pattern facilitates selective nucleophilic displacement, while the methyl group enhances metabolic stability in downstream applications. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating purification and integration into medicinal chemistry campaigns.

Synthesis

Route1
- 35265-80-6
- ~99%
- In-stock
  
  35265-82-8
References
- Nihon Nohyaku Co., Ltd. Patent: EP1544202 A1, 2005 ; Location in patent: Page/Page column 49 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 25.78
LogP 3.30652
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

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2,4-Dichloro-6-methylthieno[3,2-d]pyrimidine

CAS No. 35265-82-8

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