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CS-W001157 4
Total: USD 88.00

2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid

  • CAS No. 35264-05-2

  • Cat. No. CS-0041383
  • Purity≥97%
  • MDL No.MFCD04115511

*For research and further manufacturing use only, not for direct human use.

2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid|CS-0041383

Structure of 35264-05-2

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General Information

  • CAS No. 35264-05-2
  • Cat. No. CS-0041383
  • Purity ≥97%
  • MDL No. MFCD04115511
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₃NO₄
  • Molecular Weight 257.33
  • Synonym(s) None
  • SMILES O=C(O)C(NC(OC(C)(C)C)=O)C1CCCCC1

Description

This cyclohexyl-substituted amino acid derivative features a tert-butoxycarbonyl-protected amine, enabling stable incorporation into peptide synthesis workflows. The hydrophobic cyclohexyl moiety enhances membrane permeability, while the carboxylic acid group facilitates conjugation. Designed for modular assembly in bioactive molecule construction.

Application

2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid serves as a versatile building block for the synthesis of bioactive peptides and heterocyclic scaffolds. The Boc-protected amino group enables facile deprotection under mild acidic conditions, while the cyclohexylacetic acid moiety provides steric bulk and metabolic stability. This compound exhibits excellent bench stability, tolerates diverse reaction conditions, and facilitates purification via standard chromatographic methods. Its structure supports use in solid-phase peptide synthesis and as a precursor to cyclic amides and other medicinally relevant architectures.

Synthesis

  • Route1
    • null|null
      1070-19-5
    • Cefradine Impurity 25|CS-1002516
      20763-30-8
    • ~%
    • In-stock
      2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid|CS-0041383
      35264-05-2

    References

    • US4143133 A1, ;
  • Route2
    • null|null
      378784-00-0
    • In-stock
      Boc-Phg-OH|CS-W012629
      2900-27-8
    • ~%
    • In-stock
      2-((tert-Butoxycarbonyl)amino)-2-cyclohexylacetic acid|CS-0041383
      35264-05-2

    References

    • US5866685 A1, ;
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 36, # 3 p. 314 - 319

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.5446
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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