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CS-W001157 4
Total: USD 88.00

4-Ethynylpyridine hydrochloride

  • CAS No. 352530-29-1

  • Cat. No. CS-W002996
  • Purity≥96%
  • MDL No.MFCD03093912

*For research and further manufacturing use only, not for direct human use.

4-Ethynylpyridine hydrochloride|CS-W002996

Structure of 352530-29-1

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General Information

  • CAS No. 352530-29-1
  • Cat. No. CS-W002996
  • Purity ≥96%
  • MDL No. MFCD03093912
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClN
  • Molecular Weight 139.58
  • Synonym(s) 4-Pyridylacetylene Hydrochloride
  • SMILES C#CC1=CC=NC=C1.Cl

Description

4-Ethynylpyridine hydrochloride offers a bench-stable, moisture-tolerant platform for copper-catalyzed click chemistry. The pyridyl nitrogen enhances solubility and coordination, while the terminal alkyne enables efficient coupling in diverse synthetic workflows. This reagent integrates seamlessly into modular synthesis strategies requiring robust, functionalized building blocks.

Application

4-Ethynylpyridine hydrochloride serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated heteroaromatic systems. Its terminal alkyne functionality exhibits high reactivity in Sonogashira and CuAAC processes, while the pyridine nitrogen provides orthogonal coordination for catalysts or metal-directed functionalization. The hydrochloride salt enhances solubility and bench stability, facilitating handling and purification in synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H228-H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.4847
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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