2,3-Dichloropyrido[3,4-b]pyrazine

Name: 2,3-Dichloropyrido[3,4-b]pyrazine
Brand: ChemScene
Availability: InStock
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CAS No. 35251-99-1
Cat. No. CS-0103606
Purity≥98%
MDL No.MFCD19374272

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,3-Dichloropyrido[3,4-b]pyrazine|CS-0103606

Structure of 35251-99-1

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Description

2,3-Dichloropyrido[3,4-b]pyrazine features a rigid, electron-deficient heteroaromatic core that facilitates selective coupling reactions in medicinal chemistry. This scaffold integrates readily into kinase inhibitors and other bioactive molecules, offering enhanced metabolic stability and favorable binding interactions within target protein pockets.

Application

2,3-Dichloropyrido[3,4-b]pyrazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine and pyrazine rings via palladium-catalyzed cross-coupling reactions. Its dichloro substitution pattern offers orthogonal reactivity for sequential derivatization, while maintaining bench stability and compatibility with standard synthetic workflows. The scaffold is well-suited for constructing complex heterocyclic architectures found in kinase inhibitors and other bioactive molecules.

General Information

CAS No. 35251-99-1
Cat. No. CS-0103606
Purity ≥98%
MDL No. MFCD19374272
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃Cl₂N₃
Molecular Weight 200.02
Synonym(s) 2,3-dichloro-pyrido(3,4-b)pyrazine
SMILES ClC1=NC2=CN=CC=C2N=C1Cl

Computational Chemistry Data

TPSA 38.67
LogP 2.3316
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

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2,3-Dichloropyrido[3,4-b]pyrazine

CAS No. 35251-99-1

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