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CS-W001157 4
Total: USD 88.00

Chloromethyl ethyl carbonate

  • CAS No. 35179-98-7

  • Cat. No. CS-W005334
  • Purity≥97%
  • MDL No.MFCD00137995

*For research and further manufacturing use only, not for direct human use.

Chloromethyl ethyl carbonate|CS-W005334

Structure of 35179-98-7

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General Information

  • CAS No. 35179-98-7
  • Cat. No. CS-W005334
  • Purity ≥97%
  • MDL No. MFCD00137995
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇ClO₃
  • Molecular Weight 138.55
  • Synonym(s) carbonic acid chloromethyl ester ethyl ester
  • SMILES O=C(OCC)OCCl

Description

Chloromethyl ethyl carbonate serves as a reactive electrophilic agent in synthetic transformations, featuring a chlorine-bearing methyl group adjacent to a carbonate moiety. This structure enables selective alkylation under mild conditions, offering high functional group tolerance and compatibility with diverse reaction environments.

Application

Chloromethyl ethyl carbonate serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient introduction of both chloromethyl and ester functionalities. Its reactivity facilitates nucleophilic substitution reactions with amines, thiols, and alcohols under mild conditions, offering a reliable route to functionalized intermediates. The molecule exhibits good bench stability and ease of purification, making it well-suited for use in medicinal chemistry lead optimization and process-scale synthesis.

Synthesis

  • Route1
    • null|null
      64-17-5
    • null|null
      22128-62-7
    • ~92%
    • In-stock
      Chloromethyl ethyl carbonate|CS-W005334
      35179-98-7

    References

    • Thomas, Joshua D.; Sloan, Kenneth B. Tetrahedron Letters, 2007 , vol. 48, # 1 p. 109 - 112
  • Route2
    • null|null
      22128-62-7
    • ~%
    • In-stock
      Chloromethyl ethyl carbonate|CS-W005334
      35179-98-7

    References

    • US5977139 A1, ; US 5977139 A
  • Route3
    • null|null
      185145-45-3
    • ~70%
    • In-stock
      Chloromethyl ethyl carbonate|CS-W005334
      35179-98-7

    References

    • Hatlelid, Jostein; Benneche, Tore; Undheim, Kjell Acta Chemica Scandinavica, 1996 , vol. 50, # 11 p. 1041 - 1044

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.3558
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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