6-Fluorobenzofuran-3(2H)-one

Name: 6-Fluorobenzofuran-3(2H)-one
Brand: ChemScene
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CAS No. 351528-80-8
Cat. No. CS-0105957
Purity≥95%
MDL No.MFCD09743984

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 351528-80-8
Cat. No. CS-0105957
Purity ≥95%
MDL No. MFCD09743984
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅FO₂
Molecular Weight 152.12
Synonym(s) 6-Fluoro-3(2H)-benzofuranone
SMILES O=C1COC2=CC(F)=CC=C12

Description

6-Fluorobenzofuran-3(2H)-one features a fluorinated benzofuran core with a ketone at the 3-position, delivering enhanced electronic effects and metabolic stability. This scaffold integrates readily into medicinal chemistry campaigns, offering improved membrane permeability and targeted reactivity in synthetic transformations.

Application

6-Fluorobenzofuran-3(2H)-one serves as a versatile scaffold for the synthesis of fluorinated heterocycles and bioactive molecules. Its inherent stability, combined with electrophilic reactivity at C2 and nucleophilic potential at C3, enables efficient functionalization via palladium-catalyzed couplings and nucleophilic substitutions. The fluorine substituent enhances metabolic stability and modulates electronic properties, making it a valuable building block in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 26.3
LogP 1.4008
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic heterocycle compounds Benzofuran compounds

Key Words

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6-Fluorobenzofuran-3(2H)-one

CAS No. 351528-80-8

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