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5-Fluoro-2-methoxypyridine-3-carbaldehyde

  • CAS No. 351410-62-3

  • Cat. No. CS-0062015
  • Purity≥98%
  • MDL No.MFCD04972398

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methoxypyridine-3-carbaldehyde|CS-0062015

Structure of 351410-62-3

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General Information

  • CAS No. 351410-62-3
  • Cat. No. CS-0062015
  • Purity ≥98%
  • MDL No. MFCD04972398
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) Pyridine, 3-fluoro-2-methoxy-6-methyl-
  • SMILES COC1=NC=C(C=C1C=O)F

Description

5-Fluoro-2-methoxypyridine-3-carbaldehyde features a pyridine core bearing fluorine and methoxy substituents that modulate electronic properties, while the aldehyde group enables direct functionalization. This scaffold integrates readily into pharmaceutical intermediates and bioactive molecule frameworks.

Application

5-Fluoro-2-methoxypyridine-3-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its orthogonal functional groups—fluorine, methoxy, and aldehyde—facilitate selective transformations, including nucleophilic additions, Suzuki couplings, and reductive aminations. The aldehyde group provides a direct handle for C–C and C–N bond formation, while the pyridine core ensures compatibility with standard cross-coupling protocols. Bench-stable and readily purified by flash chromatography, it supports scalable synthesis of targeted API candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.0418
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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