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CS-W001157 4
Total: USD 88.00

5-Bromo-2-methylnicotinic acid

  • CAS No. 351003-02-6

  • Cat. No. CS-W008654
  • Purity≥96%
  • MDL No.MFCD11557230

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methylnicotinic acid|CS-W008654

Structure of 351003-02-6

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General Information

  • CAS No. 351003-02-6
  • Cat. No. CS-W008654
  • Purity ≥96%
  • MDL No. MFCD11557230
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrNO₂
  • Molecular Weight 216.03
  • Synonym(s) 5-BroMo-2-Methylpyridine-3-carboxylic acid
  • SMILES O=C(O)C1=C(C)N=CC(Br)=C1

Description

5-Bromo-2-methylnicotinic acid features a bromine substituent at the 5-position and a methyl group at the 2-position on the pyridine ring, delivering enhanced electron-withdrawing character and steric influence. This combination enables efficient coupling in cross-coupling reactions and facilitates incorporation into bioactive heterocycles under standard conditions.

Application

5-Bromo-2-methylnicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its brominated pyridine core enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid and methyl groups offer orthogonal functionalization potential. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.85072
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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