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CS-W001157 4
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2-Bromo-5-methylpyridine

  • CAS No. 3510-66-5

  • Cat. No. CS-W007353
  • Purity≥98%
  • MDL No.MFCD00209553

*For research and further manufacturing use only, not for direct human use.

2-Bromo-5-methylpyridine|CS-W007353

Structure of 3510-66-5

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General Information

  • CAS No. 3510-66-5
  • Cat. No. CS-W007353
  • Purity ≥98%
  • MDL No. MFCD00209553
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrN
  • Molecular Weight 172.02
  • Synonym(s) None
  • SMILES C1=C(Br)N=CC(=C1)C

Description

2-Bromo-5-methylpyridine has been used as starting reagent for the synthesis of:5,5-dimethyl-2,2-bipyridine5-methyl-2,2:6,2-terpyridine5-bromo-5-methyl-2,2:6,2-terpyridine

Application

2-Bromo-5-methylpyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, and Negishi couplings. The bromine atom provides high reactivity under standard conditions, while the methyl group enhances regioselectivity in electrophilic substitution and contributes to favorable solubility and bench stability. This compound functions reliably in the construction of complex pyridyl scaffolds relevant to medicinal chemistry and agrochemical development.

Synthesis

  • Route1

    References

    • Windscheif; Vogtle Synthesis, 1994 , # 1 p. 87 - 92
  • Route2
    • null|null
      108-99-6
    • ~63%
    • In-stock
      2-Bromo-5-methylpyridine|CS-W007353
      3510-66-5

    References

    • Mathieu, Julien; Gros, Philippe; Fort, Yves Chemical Communications, 2000 , # 11 p. 951 - 952
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 68, p. 2574,2576

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.15252
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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