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Structure of 351-52-0
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4-(Chloromethyl)-2-fluoro-1-methoxybenzene features a reactive chloromethyl group flanked by electron-withdrawing fluorine and electron-donating methoxy substituents, enabling selective functionalization in cross-coupling and nucleophilic substitution reactions. This aryl halide derivative exhibits enhanced stability under standard bench conditions and integrates readily into complex molecular architectures.
4-(Chloromethyl)-2-fluoro-1-methoxybenzene serves as a versatile aryl building block for medicinal chemistry and materials synthesis, enabling direct functionalization via nucleophilic substitution at the chloromethyl group. The ortho-fluoro and para-methoxy substituents provide favorable electronic tuning and enhanced metabolic stability in bioactive scaffolds. Its bench-stable, crystalline form facilitates handling and purification, while compatibility with standard coupling reactions supports efficient assembly of complex heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: