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CS-W001157 4
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N-(4-(Trifluoromethyl)phenyl)acetamide

  • CAS No. 349-97-3

  • Cat. No. CS-0145352
  • Purity≥98%
  • MDL No.MFCD00013562

*For research and further manufacturing use only, not for direct human use.

N-(4-(Trifluoromethyl)phenyl)acetamide|CS-0145352

Structure of 349-97-3

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General Information

  • CAS No. 349-97-3
  • Cat. No. CS-0145352
  • Purity ≥98%
  • MDL No. MFCD00013562
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈F₃NO
  • Molecular Weight 203.16
  • Synonym(s) N-[4-(Trifluoromethyl)phenyl]acetamide
  • SMILES CC(NC1=CC=C(C(F)(F)F)C=C1)=O

Description

N-(4-(Trifluoromethyl)phenyl)acetamide features a trifluoromethyl-substituted phenyl ring paired with an acetamide linkage, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables robust integration into pharmaceutical scaffolds and facilitates efficient coupling in synthetic workflows under standard conditions.

Application

N-(4-(Trifluoromethyl)phenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized aryl amides through standard coupling and reduction protocols. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the acetamide moiety offers predictable reactivity in amide bond formation and derivatization. Bench-stable and readily purified by recrystallization, it functions reliably in multistep synthesis of bioactive scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P340-P362-P403-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.6638
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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