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CS-W001157 4
Total: USD 88.00

(4-(Trifluoromethyl)phenyl)methanol

  • CAS No. 349-95-1

  • Cat. No. CS-0005960
  • Molecule weight176.14
  • Purity≥97%
  • MDL No.MFCD00004661

*For research and further manufacturing use only, not for direct human use.

(4-(Trifluoromethyl)phenyl)methanol|CS-0005960

Structure of 349-95-1

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General Information

  • CAS No. 349-95-1
  • Cat. No. CS-0005960
  • Purity ≥97%
  • MDL No. MFCD00004661
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₃O
  • Molecular Weight 176.14
  • Synonym(s) N1-[4-(trifluoromethyl)phenyl]acetamide
  • SMILES OCC1=CC=C(C(F)(F)F)C=C1

Description

This trifluoromethyl-substituted benzyl alcohol features a robust aryl moiety with enhanced electron-withdrawing character, enabling efficient incorporation into pharmaceutical intermediates and functional materials. The hydroxymethyl group supports direct derivatization under standard conditions, while the fluorinated ring imparts metabolic stability and improved lipophilicity for bioactive compound design.

Synthesis

  • Route1

    References

    • Nagendra; Madhu; Vishwanatha; Sureshbabu, Vommina V. Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5059 - 5063
  • Route2

    References

    • Fernandez-Salas, Jose A.; Manzini, Simone; Nolan, Steven P. Chemical Communications, 2013 , vol. 49, # 84 p. 9758 - 9760
  • Route3

    References

    • Li, Lian-Hai; Chan, Tak Hang Organic Letters, 2000 , vol. 2, # 8 p. 1129 - 1131

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.1977
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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