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CS-W001157 4
Total: USD 88.00

4-Chlorobenzenesulfonyl fluoride

  • CAS No. 349-89-3

  • Cat. No. CS-0133611
  • Purity≥95%
  • MDL No.MFCD01657965

*For research and further manufacturing use only, not for direct human use.

4-Chlorobenzenesulfonyl fluoride|CS-0133611

Structure of 349-89-3

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General Information

  • CAS No. 349-89-3
  • Cat. No. CS-0133611
  • Purity ≥95%
  • MDL No. MFCD01657965
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClFO₂S
  • Molecular Weight 194.61
  • Synonym(s) Benzenesulfonyl fluoride, 4-chloro- (9CI)
  • SMILES O=S(C1=CC=C(Cl)C=C1)(F)=O

Application

4-Chlorobenzenesulfonyl fluoride serves as a versatile sulfonylating agent for the efficient introduction of sulfonamide groups under mild conditions. Its reactivity enables direct functionalization of amines and heterocyclic nitrogen centers with high chemoselectivity, facilitating synthesis of bioactive sulfonamide derivatives. The molecule exhibits good bench stability and is compatible with diverse functional groups, enabling straightforward purification via standard chromatographic methods.

Synthesis

  • Route1

    References

    • Kirihara, Masayuki; Naito, Sayuri; Nishimura, Yuki; Ishizuka, Yuki; Iwai, Toshiaki; Takeuchi, Haruka; Ogata, Tomomi; Hanai, Honoka; Kinoshita, Yukari; Kishida, Mari; Yamazaki, Kento; Noguchi, Takuya; Yamashoji, Shiro Tetrahedron, 2014 , vol. 70, # 14 p. 2464 - 2471
  • Route2
    • null|null
      1146-44-7
    • ~96%
    • In-stock
      4-Chlorobenzenesulfonyl fluoride|CS-0133611
      349-89-3

    References

    • Kirihara, Masayuki; Naito, Sayuri; Nishimura, Yuki; Ishizuka, Yuki; Iwai, Toshiaki; Takeuchi, Haruka; Ogata, Tomomi; Hanai, Honoka; Kinoshita, Yukari; Kishida, Mari; Yamazaki, Kento; Noguchi, Takuya; Yamashoji, Shiro Tetrahedron, 2014 , vol. 70, # 14 p. 2464 - 2471
  • Route3
    • In-stock
      1,2-Bis(4-chlorophenyl)disulfane|CS-W013999
      1142-19-4
    • ~9%
    • null|null
      1146-44-7
    • In-stock
      4-Chlorobenzenesulfonyl fluoride|CS-0133611
      349-89-3

    References

    • Kirihara, Masayuki; Naito, Sayuri; Nishimura, Yuki; Ishizuka, Yuki; Iwai, Toshiaki; Takeuchi, Haruka; Ogata, Tomomi; Hanai, Honoka; Kinoshita, Yukari; Kishida, Mari; Yamazaki, Kento; Noguchi, Takuya; Yamashoji, Shiro Tetrahedron, 2014 , vol. 70, # 14 p. 2464 - 2471

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.9982
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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