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CS-W001157 4
Total: USD 88.00

3-Methoxy-5-(trifluoromethyl)aniline

  • CAS No. 349-55-3

  • Cat. No. CS-W015851
  • Purity≥98%
  • MDL No.MFCD00000393

*For research and further manufacturing use only, not for direct human use.

3-Methoxy-5-(trifluoromethyl)aniline|CS-W015851

Structure of 349-55-3

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General Information

  • CAS No. 349-55-3
  • Cat. No. CS-W015851
  • Purity ≥98%
  • MDL No. MFCD00000393
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈F₃NO
  • Molecular Weight 191.15
  • Synonym(s) 3-Amino-5-methoxybenzotrifluoride
  • SMILES NC1=CC(C(F)(F)F)=CC(OC)=C1

Description

3-Methoxy-5-(trifluoromethyl)aniline features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the methoxy substituent provides a polar handle for further functionalization. This combination enables efficient integration into bioactive scaffolds and advanced materials.

Application

3-Methoxy-5-(trifluoromethyl)aniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the methoxy substituent offers predictable regioselectivity in electrophilic substitution. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for multi-step synthetic sequences in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.2962
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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