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CS-W001157 4
Total: USD 88.00

2-Ethyl-1H-indole

  • CAS No. 3484-18-2

  • Cat. No. CS-0119999
  • Molecule weight145.21
  • Purity≥97%
  • MDL No.MFCD00049343

*For research and further manufacturing use only, not for direct human use.

2-Ethyl-1H-indole|CS-0119999

Structure of 3484-18-2

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General Information

  • CAS No. 3484-18-2
  • Cat. No. CS-0119999
  • Purity ≥97%
  • MDL No. MFCD00049343
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁N
  • Molecular Weight 145.21
  • Synonym(s) None
  • SMILES CCC(N1)=CC2=C1C=CC=C2

Description

2-Ethyl-1H-indole features a sterically hindered ethyl substituent at the 2-position of the indole core, enhancing its stability and solubility in organic media. This structural motif enables efficient integration into complex heterocyclic architectures, particularly in pharmaceutical intermediates and functional materials.

Application

2-Ethyl-1H-indole serves as a versatile building block in synthetic organic chemistry, particularly for the construction of indole-based pharmaceutical scaffolds. Its ethyl substituent at the 2-position enhances electronic modulation and steric profile, enabling predictable reactivity in electrophilic substitution and transition-metal-catalyzed coupling reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      97-94-9
    • null|null
      167558-54-5
    • ~76%
    • In-stock
      2-Ethyl-1H-indole|CS-0119999
      3484-18-2

    References

    • LAUTENS, Mark; FANG, Yuanqing Patent: WO2006/47888 A1, 2006 ; Location in patent: Page/Page column 64; 102-103 ;
  • Route2
    • null|null
      74-88-4
    • ~68%
    • In-stock
      2-Ethyl-1H-indole|CS-0119999
      3484-18-2

    References

    • NOVO NORDISK A/S Patent: WO2006/82245 A1, 2006 ; Location in patent: Page/Page column 160 ;
  • Route3
    • null|null
      68051-21-8
    • ~99%
    • In-stock
      2-Ethyl-1H-indole|CS-0119999
      3484-18-2

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH Patent: US2011/21500 A1, 2011 ; Location in patent: Page/Page column 48 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   2.7303
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   1

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