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CS-W001157 4
Total: USD 88.00

Methyl 2-(4-fluorophenyl)acetate

  • CAS No. 34837-84-8

  • Cat. No. CS-W008065
  • Purity≥98%
  • MDL No.MFCD00800608

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(4-fluorophenyl)acetate|CS-W008065

Structure of 34837-84-8

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General Information

  • CAS No. 34837-84-8
  • Cat. No. CS-W008065
  • Purity ≥98%
  • MDL No. MFCD00800608
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₂
  • Molecular Weight 168.16
  • Synonym(s) Methyl 4-Fluorophenylacetate, 99
  • SMILES O=C(OC)CC1=CC=C(F)C=C1

Description

Methyl 2-(4-fluorophenyl)acetate is a bench-stable, moisture-tolerant aryl ketone precursor featuring a fluorinated phenyl ring that enhances metabolic stability. This electrophilic moiety integrates readily into pharmaceutical intermediates and serves as a key building block in the synthesis of bioactive compounds requiring electron-deficient aromatic systems.

Application

Methyl 2-(4-fluorophenyl)acetate serves as a versatile building block in medicinal chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its benzylic ester functionality exhibits robust stability under standard reaction conditions and tolerates a range of functional groups, facilitating downstream transformations such as reduction, hydrolysis, or coupling reactions. The 4-fluorophenyl moiety enhances metabolic stability and modulates electronic properties, making this compound a practical choice for synthesizing pharmaceutically relevant intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.5412
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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