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CS-W001157 4
Total: USD 88.00

1-(3-(Trifluoromethoxy)phenyl)ethanol

  • CAS No. 347194-02-9

  • Cat. No. CS-W015335
  • Molecule weightNone
  • Purity≥98%
  • MDL No.MFCD06797343

*For research and further manufacturing use only, not for direct human use.

1-(3-(Trifluoromethoxy)phenyl)ethanol|CS-W015335

Structure of 347194-02-9

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General Information

  • CAS No. 347194-02-9
  • Cat. No. CS-W015335
  • Purity ≥98%
  • MDL No. MFCD06797343
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉F₃O₂
  • Molecular Weight None
  • Synonym(s) 1-[3-(Trifluoromethoxy)phenyl]ethan-1-ol
  • SMILES CC(O)C1=CC=CC(OC(F)(F)F)=C1

Description

1-(3-(Trifluoromethoxy)phenyl)ethanol features a trifluoromethoxy-substituted phenyl ring linked to a chiral ethanol backbone, delivering enhanced lipophilicity and metabolic stability. This bench-stable scaffold integrates readily into pharmaceutical intermediates, enabling efficient access to bioactive molecules through modular derivatization pathways.

Application

1-(3-(Trifluoromethoxy)phenyl)ethanol serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive arylalkyl scaffolds. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the secondary alcohol facilitates straightforward derivatization via esterification, oxidation, or protection. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis campaigns in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.6385
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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