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CS-W001157 4
Total: USD 88.00

(S)-2-((tert-Butoxycarbonyl)amino)-3-(perfluorophenyl)propanoic acid

  • CAS No. 34702-60-8

  • Cat. No. CS-W009796
  • Purity≥95%
  • MDL No.MFCD00151893

*For research and further manufacturing use only, not for direct human use.

(S)-2-((tert-Butoxycarbonyl)amino)-3-(perfluorophenyl)propanoic acid|CS-W009796

Structure of 34702-60-8

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General Information

  • CAS No. 34702-60-8
  • Cat. No. CS-W009796
  • Purity ≥95%
  • MDL No. MFCD00151893
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₄F₅NO₄
  • Molecular Weight 355.26
  • Synonym(s) Boc-pentafluoro-Phe-OH
  • SMILES O=C(O)[C@H](CC1=C(F)C(F)=C(F)C(F)=C1F)NC(OC(C)(C)C)=O

Description

This chiral building block features a protected amino group and a perfluorophenyl moiety, enabling efficient coupling reactions in peptide synthesis. The electron-deficient aryl group enhances reactivity in nucleophilic substitution processes, while the tert-butyl ester provides stable storage and selective deprotection under mild acidic conditions.

Application

(S)-2-((tert-Butoxycarbonyl)amino)-3-(perfluorophenyl)propanoic acid serves as a versatile building block for peptide and peptidomimetic synthesis, combining a stable Boc-protected amine with a highly reactive perfluorophenyl ester. The perfluorophenyl group enables efficient coupling to amines under mild conditions, facilitating rapid amide bond formation with high yield and minimal racemization. Its bench-stable solid form simplifies handling and purification, making it ideal for iterative synthetic workflows in medicinal chemistry and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.9025
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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