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CS-W001157 4
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2-Chloro-6-(trifluoromethyl)pyridin-4-amine

  • CAS No. 34486-22-1

  • Cat. No. CS-0051937
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-(trifluoromethyl)pyridin-4-amine|CS-0051937

Structure of 34486-22-1

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General Information

  • CAS No. 34486-22-1
  • Cat. No. CS-0051937
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₃N₂
  • Molecular Weight 196.56
  • Synonym(s) T6NJ BXFFF DZ FG
  • SMILES NC1=CC(=NC(Cl)=C1)C(F)(F)F

Description

2-Chloro-6-(trifluoromethyl)pyridin-4-amine features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the chloro substituent enables selective coupling reactions. This pyridine scaffold integrates readily into pharmaceutical intermediates and agrochemicals, offering high reactivity under standard conditions with excellent bench stability.

Application

2-Chloro-6-(trifluoromethyl)pyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro and amine functionalities offer orthogonal reactivity for further functionalization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.336
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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