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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethyl)pyridin-2-ol

  • CAS No. 34486-06-1

  • Cat. No. CS-0002285
  • Purity≥97%
  • MDL No.MFCD08061317

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)pyridin-2-ol|CS-0002285

Structure of 34486-06-1

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General Information

  • CAS No. 34486-06-1
  • Cat. No. CS-0002285
  • Purity ≥97%
  • MDL No. MFCD08061317
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₃NO
  • Molecular Weight 163.10
  • Synonym(s) 2-hydroxy-6-(trifluoromethyl) pyridine
  • SMILES O=C1NC(C(F)(F)F)=CC=C1

Description

6-(Trifluoromethyl)pyridin-2-ol features a trifluoromethyl group at the 6-position and a phenolic hydroxyl at the 2-position, creating a uniquely electron-deficient pyridinic scaffold. This configuration enhances its utility in transition-metal-catalyzed coupling reactions and as a building block for bioactive heterocycles. The compound exhibits robust stability under standard bench conditions and demonstrates favorable solubility in common organic solvents.

Application

6-(Trifluoromethyl)pyridin-2-ol serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a trifluoromethyl group adjacent to a phenolic hydroxyl. Its reactivity facilitates efficient derivatization via etherification, esterification, or metal-catalyzed coupling reactions. The molecule exhibits good bench stability and functional group tolerance, making it well-suited for modular synthesis of bioactive heterocycles and API intermediates.

Synthesis

  • Route1

    References

    • Zeneca Limited Patent: US5973159 A1, 1999 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   1.3937
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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