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CS-W001157 4
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Butyl (S)-2-hydroxypropanoate

  • CAS No. 34451-19-9

  • Cat. No. CS-0451298
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Butyl (S)-2-hydroxypropanoate|CS-0451298

Structure of 34451-19-9

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General Information

  • CAS No. 34451-19-9
  • Cat. No. CS-0451298
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄O₃
  • Molecular Weight 146.18
  • Synonym(s) Propanoic acid, 2-hydroxy-, butyl ester, (2S)-
  • SMILES CCCCOC(=O)[C@H](C)O

Description

Tos-PEG4-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Synthesis

  • Route1
    • Butyl 2-oxopropanoate|CS-0449459
      20279-44-1
    • ~%
    • In-stock
      Butyl (S)-2-hydroxypropanoate|CS-0451298
      34451-19-9
    • null|null
      34451-18-8

    References

    • Tetrahedron, , vol. 55, # 25 p. 7787 - 7804
  • Route2
    • In-stock
      (3R,6R)-3,6-Dimethyl-1,4-dioxane-2,5-dione|CS-0158241
      13076-17-0
    • null|null
      71-36-3
    • ~91%
    • In-stock
      Butyl (S)-2-hydroxypropanoate|CS-0451298
      34451-19-9

    References

    • Phomphrai, Khamphee; Pracha, Supathana; Phonjanthuek, Phenphak; Pohmakotr, Manat Dalton Transactions, 2008 , # 23 p. 3048 - 3050
  • Route3
    • Butyl 2-oxopropanoate|CS-0449459
      20279-44-1
    • ~%
    • In-stock
      Butyl (S)-2-hydroxypropanoate|CS-0451298
      34451-19-9

    References

    • Journal of Organic Chemistry, , vol. 42, p. 1671 - 1679

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   0.7105
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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