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CS-W001157 4
Total: USD 88.00

3-Bromopiperidin-2-one

  • CAS No. 34433-86-8

  • Cat. No. CS-0072629
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromopiperidin-2-one|CS-0072629

Structure of 34433-86-8

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General Information

  • CAS No. 34433-86-8
  • Cat. No. CS-0072629
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈BrNO
  • Molecular Weight 178.03
  • Synonym(s) None
  • SMILES O=C1NCCCC1Br

Description

3-Bromopiperidin-2-one is a versatile heterocyclic building block featuring a bromine atom at the 3-position and a ketone functionality at the 2-position. This combination enables direct functionalization in cross-coupling reactions and facilitates downstream derivatization in medicinal chemistry. The molecule exhibits favorable stability under standard conditions, supporting its use in multi-step syntheses.

Application

3-Bromopiperidin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of nitrogen-containing heterocycles. The bromine at C3 provides a reliable site for palladium-catalyzed cross-coupling reactions, while the amide functionality offers stability and orthogonal reactivity. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for modular synthesis workflows.

Synthesis

  • Route1
    • 3,3-Dibromopiperidin-2-one|CS-0149746
      26228-95-5
    • ~91%
    • In-stock
      3-Bromopiperidin-2-one|CS-0072629
      34433-86-8

    References

    • Uchikawa, Osamu; Aono, Tetsuya Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1545 - 1552
  • Route2
    • null|null
      614754-00-6
    • ~40%
    • In-stock
      3-Bromopiperidin-2-one|CS-0072629
      34433-86-8

    References

    • Kamal, Ahmed; Ramana, K. Venkata; Ramana, A. Venkata; Babu, A. Hari Tetrahedron Asymmetry, 2003 , vol. 14, # 17 p. 2587 - 2594
  • Route3

    References

    • Uchikawa, Osamu; Aono, Tetsuya Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1545 - 1552

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.6599
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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