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Structure of 344-72-9
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2-Amino-4-(trifluoromethyl)-5-(carbethoxy)thiazole features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, while the carbethoxy moiety provides a handle for derivatization. This thiazole scaffold integrates into bioactive molecule design, offering robustness under standard bench conditions and compatibility with diverse synthetic transformations.
2-Amino-4-(trifluoromethyl)-5-(carbethoxy)thiazole serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiazole-based heterocycles with enhanced metabolic stability. The amino group facilitates nucleophilic substitution and coupling reactions, while the trifluoromethyl and carbethoxy functionalities offer favorable electronic effects and orthogonal reactivity. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for iterative functionalization and API scaffold development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: