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Structure of 343868-74-6
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8-Chloroquinolin-2-amine delivers a potent electron-deficient quinoline scaffold bearing a reactive amine handle. This configuration enables direct incorporation into bioactive molecule design, particularly in kinase inhibitors and metal-chelating ligands. The chlorine substituent enhances metabolic stability and facilitates downstream functionalization via cross-coupling.
8-Chloroquinolin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinoline-based scaffolds. Its chlorine substituent enhances electrophilicity for palladium-catalyzed cross-coupling reactions, while the primary amine facilitates derivatization via acylation, alkylation, or condensation. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: