Lot numbers can be found on the outside label of a product:
3-Bromo-4-methylpyridine
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CAS No. 3430-22-6
- Cat. No. CS-W019971
- Purity≥98%
- MDL No.MFCD00082592
*For research and further manufacturing use only, not for direct human use.
Structure of 3430-22-6
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General Information
- CAS No. 3430-22-6
- Cat. No. CS-W019971
- Purity ≥98%
- MDL No. MFCD00082592
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₆BrN
- Molecular Weight 172.02
- Synonym(s) 3-Bromo-4-picoline; 3-Bromo-4-methylpyridine
- SMILES CC1=CC=NC=C1Br
Description
3-Bromo-4-methylpyridine is a halogenated pyridine derivative featuring a methyl group at the 4-position and a bromine substituent at the 3-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to construct complex nitrogen-containing scaffolds. The molecule exhibits enhanced reactivity due to the combined influence of the electron-withdrawing bromine and adjacent electron-donating methyl group.
Application
3-Bromo-4-methylpyridine serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity profile. The bromine substituent provides reliable functionalization potential, while the methyl group enhances electron density at the pyridine ring, improving regioselectivity in subsequent transformations. Its bench-stable nature and compatibility with standard purification methods make it ideal for modular heterocycle construction and API intermediate development.
Synthesis
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Route1
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108-89-4 - ~19%
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In-stock
3430-22-6
References
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Imbert, Thierry; Monse, Barbara; Koek, Wouter Patent: US2005/80085 A1, 2005 ; Location in patent: Page/Page column 12 ;
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Route2
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90731-85-4
- ~%
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In-stock
3430-22-6
References
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Heterocycles, , vol. 22, # 2 p. 339 - 344
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Route3
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In-stock
626-55-1 - ~%
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In-stock
3430-22-6
References
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Heterocycles, , vol. 22, # 2 p. 339 - 344
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 2.15252
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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