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CS-W001157 4
Total: USD 88.00

2-(1H-Indol-5-yl)acetic acid

  • CAS No. 34298-84-5

  • Cat. No. CS-0055752
  • Purity≥97%
  • MDL No.MFCD09837609

*For research and further manufacturing use only, not for direct human use.

2-(1H-Indol-5-yl)acetic acid|CS-0055752

Structure of 34298-84-5

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General Information

  • CAS No. 34298-84-5
  • Cat. No. CS-0055752
  • Purity ≥97%
  • MDL No. MFCD09837609
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO₂
  • Molecular Weight None
  • Synonym(s) 1H-indol-5-ylacetic acid
  • SMILES C1=CC2=C(C=CN2)C=C1CC(=O)O

Description

This indole derivative features a carboxylic acid group at the 2-position, enabling direct conjugation or derivatization. The indolyl moiety imparts strong π-electron density and planar rigidity, enhancing binding affinity in bioactive molecule design. Stable under standard bench conditions, it serves as a key scaffold for pharmaceutical intermediates and chemical biology probes.

Application

2-(1H-Indol-5-yl)acetic acid serves as a versatile building block for the synthesis of indole-containing bioactive molecules, enabling efficient conjugation via amide and ester linkages. Its carboxylic acid functionality offers high reactivity in standard coupling protocols, while the indole moiety provides a stable, aromatic scaffold compatible with diverse functional group transformations. Bench-stable and readily purified by recrystallization, it functions reliably in medicinal chemistry campaigns targeting CNS-active compounds and peptide conjugates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   1.795
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   2

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