Imidazo[1,2-a]pyridin-7-ylmethanol

Name: Imidazo[1,2-a]pyridin-7-ylmethanol
Brand: ChemScene
Availability: InStock
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CAS No. 342613-80-3
Cat. No. CS-0049339
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Imidazo[1,2-a]pyridin-7-ylmethanol|CS-0049339

Structure of 342613-80-3

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General Information

CAS No. 342613-80-3
Cat. No. CS-0049339
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈N₂O
Molecular Weight 148.16
Synonym(s) Imidazo[1,2-A]pyridine-7-methanol
SMILES OCC1=CC2=NC=CN2C=C1

Description

Imidazo[1,2-a]pyridin-7-ylmethanol serves as a versatile heterocyclic building block for medicinal chemistry and materials science. This bench-stable scaffold integrates readily into diverse molecular architectures, featuring a polar hydroxymethyl group that enables downstream functionalization. The fused imidazopyridine core imparts rigidity and enhanced electron density, supporting applications in kinase inhibitors and fluorescent probes.

Application

Imidazo[1,2-a]pyridin-7-ylmethanol serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds through standard functional group transformations. Its bench-stable nature and compatibility with diverse reaction conditions facilitate straightforward derivatization, including oxidation to aldehydes or carboxylic acids, and incorporation into pharmaceutical intermediates via coupling reactions.

Synthesis

Route1
- 107-20-0
- In-stock
  
  105250-17-7
- ~78%
- In-stock
  
  342613-80-3
References
- SCHERING CORPORATION Patent: WO2007/1975 A1, 2007 ; Location in patent: Page/Page column 51 ; WO 2007/001975 A1
Route2
- 372147-49-4
- ~77%
- In-stock
  
  342613-80-3
References
- Chezal; Moreau; Delmas; Gueiffier; Blache; Grassy; Lartigue; Chavignon; Teulade Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6576 - 6584
Route3
- In-stock
  
  13362-30-6
- ~%
- In-stock
  
  342613-80-3
References
- Journal of Organic Chemistry, , vol. 66, # 20 p. 6576 - 6584

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 37.53
LogP 0.8266
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Imidazo[1,2-a]pyridin-7-ylmethanol

CAS No. 342613-80-3

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