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CS-W001157 4
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1-(6-Bromopyridin-2-yl)propan-1-one

  • CAS No. 341556-25-0

  • Cat. No. CS-0059800
  • Purity≥97%
  • MDL No.MFCD27949663

*For research and further manufacturing use only, not for direct human use.

1-(6-Bromopyridin-2-yl)propan-1-one|CS-0059800

Structure of 341556-25-0

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General Information

  • CAS No. 341556-25-0
  • Cat. No. CS-0059800
  • Purity ≥97%
  • MDL No. MFCD27949663
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO
  • Molecular Weight 214.06
  • Synonym(s) 1-(6-bromo-2-pyridinyl)-1-propanone
  • SMILES CCC(C1=NC(Br)=CC=C1)=O

Description

1-(6-Bromopyridin-2-yl)propan-1-one features a brominated pyridine ring linked to a ketone-functionalized propyl chain, enabling direct incorporation into cross-coupling reactions. The electron-deficient pyridine moiety enhances reactivity in palladium-catalyzed transformations, while the bench-stable ketone group supports straightforward derivatization. This compound serves as a key building block for functionalized heterocycles in medicinal chemistry and materials science.

Application

1-(6-Bromopyridin-2-yl)propan-1-one serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The bromine atom facilitates palladium-catalyzed coupling with boronic acids, esters, and other nucleophiles under standard conditions. Its ketone functionality provides additional handle for further functionalization, including enolate chemistry and reductive amination. Bench-stable and readily purified by flash chromatography, it supports scalable synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   2.4368
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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