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CS-W001157 4
Total: USD 88.00

5-Hydroxy-1H-indole-3-carbaldehyde

  • CAS No. 3414-19-5

  • Cat. No. CS-W022389
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Hydroxy-1H-indole-3-carbaldehyde|CS-W022389

Structure of 3414-19-5

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General Information

  • CAS No. 3414-19-5
  • Cat. No. CS-W022389
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇NO₂
  • Molecular Weight 161.16
  • Synonym(s) 1H-indole-3-carboxaldehyde, 5-hydroxy-
  • SMILES O=CC1=CNC2=C1C=C(O)C=C2

Description

5-Hydroxy-1H-indole-3-carbaldehyde features a strategically positioned aldehyde group flanked by a hydroxyl and indole scaffold, enabling direct integration into bioactive molecule synthesis. This electron-rich heterocycle exhibits enhanced solubility in polar solvents and stability under standard bench conditions, facilitating its use in medicinal chemistry campaigns targeting serotonin receptor modulators and fluorescent probes.

Application

5-Hydroxy-1H-indole-3-carbaldehyde serves as a versatile building block for heterocyclic synthesis, enabling efficient access to indole-based scaffolds through standard functional group transformations. The aldehyde functionality facilitates reductive amination, condensation, and coupling reactions, while the phenolic hydroxyl group supports derivatization or protection strategies. Its bench-stable nature and compatibility with common reaction conditions make it suitable for medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • In-stock
      5-Hydroxyindole|CS-W001160
      1953-54-4
    • null|null
      68-12-2
    • ~86%
    • In-stock
      5-Hydroxy-1H-indole-3-carbaldehyde|CS-W022389
      3414-19-5

    References

    • Pedras, M. Soledade C.; Khan, Abdul Q. Phytochemistry, 2000 , vol. 53, # 1 p. 59 - 69

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   1.686
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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