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CS-W001157 4
Total: USD 88.00

PEG2-bis(Alkyne)

  • CAS No. 3386-87-6

  • Cat. No. CS-0158479
  • Purity≥98%
  • MDL No.MFCD00019871

*For research and further manufacturing use only, not for direct human use.

PEG2-bis(Alkyne)|CS-0158479

Structure of 3386-87-6

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General Information

  • CAS No. 3386-87-6
  • Cat. No. CS-0158479
  • Purity ≥98%
  • MDL No. MFCD00019871
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₂O₂
  • Molecular Weight 168.20
  • Synonym(s) None
  • SMILES N#CCCOCCOCCC#N

Description

This bifunctional nitrile compound features two nitrile groups linked by an ethylene glycol spacer, enabling precise molecular architecture in polymer synthesis and supramolecular design. The ether bridge enhances solubility and stability under standard conditions.

Application

3,3'-(Ethane-1,2-diylbis(oxy))dipropanenitrile serves as a versatile bifunctional building block for the synthesis of macrocyclic and linear oligomeric architectures. Its two nitrile groups flanking a rigid ethylene glycol spacer enable efficient coupling reactions, including amidation and nucleophilic substitution, with predictable regiochemistry. The molecule exhibits excellent bench stability, solubility in common organic solvents, and compatibility with standard purification techniques, facilitating its use in multistep syntheses of functionalized polymers and complex heterocycles.

Synthesis

  • Route1
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • null|null
      107-13-1
    • ~82%
    • In-stock
      PEG2-bis(Alkyne)|CS-0158479
      3386-87-6

    References

    • Kataky, Ritu; Nicholson, Patrick E. Patrick; Parker, David Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1990 , # 2 p. 321 - 327
  • Route2
    • In-stock
      Ethylene glycol,98%|CS-0015059
      107-21-1
    • null|null
      107-13-1
    • ~%
    • null|null
      1656-48-0
    • In-stock
      PEG2-bis(Alkyne)|CS-0158479
      3386-87-6

    References

    • US2014/18567 A1, ; Paragraph 0058-0060 ;
  • Route3

    References

    • Tetrahedron Letters, , vol. 45, # 52 p. 9529 - 9531

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 3276
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.04
  • LogP   0.84696
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   7

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