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CS-W001157 4
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1-Methyl-1H-pyrazol-5-ol

  • CAS No. 33641-15-5

  • Cat. No. CS-W008402
  • Purity≥96%
  • MDL No.MFCD05864418

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-pyrazol-5-ol|CS-W008402

Structure of 33641-15-5

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General Information

  • CAS No. 33641-15-5
  • Cat. No. CS-W008402
  • Purity ≥96%
  • MDL No. MFCD05864418
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆N₂O
  • Molecular Weight 98.10
  • Synonym(s) N-Heptyl isocyanate
  • SMILES OC1=CC=N[N]1C

Description

1-Methyl-1H-pyrazol-5-ol is a bench-stable heterocyclic compound featuring a phenolic hydroxyl group and a methylated pyrazole core. This structure imparts enhanced solubility and electronic modulation, enabling direct incorporation into bioactive scaffolds. The molecule serves as a versatile synthon in medicinal chemistry, particularly for designing kinase inhibitors and modulators of protein-protein interactions.

Application

1-Methyl-1H-pyrazol-5-ol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization protocols. Its phenolic hydroxyl group offers moderate reactivity for derivatization, while the pyrazole scaffold provides metabolic stability and favorable pharmacokinetic properties. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1
    • In-stock
      Methyl 3-methoxyacrylate|CS-W007972
      34846-90-7
    • null|null
      60-34-4
    • ~70%
    • In-stock
      1-Methyl-1H-pyrazol-5-ol|CS-W008402
      33641-15-5

    References

    • PFIZER JAPAN INC.; PFIZER INC.; RENOVIS, INC. Patent: WO2008/59370 A2, 2008 ; Location in patent: Page/Page column 49 ; WO 2008/059370 A2
  • Route2
    • In-stock
      (E)-Methyl 3-methoxyacrylate|CS-0076974
      5788-17-0
    • null|null
      60-34-4
    • ~%
    • In-stock
      1-Methyl-1H-pyrazol-5-ol|CS-W008402
      33641-15-5

    References

    • WO2009/69044 A1, ; Page/Page column 130; 141 ; WO 2009/069044 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   0.1257
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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