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CS-W001157 4
Total: USD 88.00

3-Methyl-[1,2,4]triazolo[4,3-a]pyrazine

  • CAS No. 33590-17-9

  • Cat. No. CS-0097059
  • Purity≥97%
  • MDL No.MFCD11111696

*For research and further manufacturing use only, not for direct human use.

3-Methyl-[1,2,4]triazolo[4,3-a]pyrazine|CS-0097059

Structure of 33590-17-9

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General Information

  • CAS No. 33590-17-9
  • Cat. No. CS-0097059
  • Purity ≥97%
  • MDL No. MFCD11111696
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₄
  • Molecular Weight 134.14
  • Synonym(s) 3-Methyl-1,2,4-triazolo[4,3-a]pyrazine
  • SMILES CC1=NN=C2C=NC=CN21

Description

3-Methyl-[1,2,4]triazolo[4,3-a]pyrazine is a heterocyclic scaffold featuring a fused triazolopyrazine core with a methyl substituent at the 3-position. This electron-deficient system integrates readily into medicinal chemistry libraries, offering enhanced metabolic stability and favorable binding interactions in target-directed synthesis.

Application

3-Methyl-[1,2,4]triazolo[4,3-a]pyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of complex nitrogen-rich scaffolds. Its stability under standard reaction conditions and tolerance to diverse functional groups facilitate downstream derivatization. The fused triazolopyrazine core provides a rigid, planar framework ideal for target-oriented synthesis and structure-activity studies.

Synthesis

  • Route1
    • Ethyl ethanedithioate|CS-1058164
      870-73-5
    • In-stock
      2-Hydrazinopyrazine|CS-M3641
      54608-52-5
    • ~21%
    • In-stock
      3-Methyl-[1,2,4]triazolo[4,3-a]pyrazine|CS-0097059
      33590-17-9

    References

    • Khadem, H. S. El; Kawai, J.; Swartz, D. L. Heterocycles, 1989 , vol. 28, # 1 p. 239 - 248

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.08
  • LogP   0.43272
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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