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tert-Butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-yl)carbamate

  • CAS No. 335592-60-4

  • Cat. No. CS-0035503
  • Molecule weight361.28
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-yl)carbamate|CS-0035503

Structure of 335592-60-4

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General Information

  • CAS No. 335592-60-4
  • Cat. No. CS-0035503
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₃₂BNO₄
  • Molecular Weight 361.28
  • Synonym(s) 4-[2-(Boc-amino)-2-propyl]phenylboronic Acid Pinacol Ester
  • SMILES CC(C)(C)OC(=O)NC(C)(C)C1=CC=C(C=C1)B2OC(C)(C)C(C)(C)O2

Description

t-Butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-yl)carbamate is a bench-stable boronate ester featuring a sterically shielded tetramethyl-1,3,2-dioxaborolane moiety. This robust reagent integrates seamlessly into Suzuki-Miyaura coupling protocols, enabling efficient C–C bond formation under mild conditions. The protecting group enhances solubility and stability during handling and storage.

Application

tert-Butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-yl)carbamate serves as a robust boron-containing building block for Suzuki-Miyaura cross-coupling reactions. Its tert-butyl carbamate group provides excellent bench stability and facilitates purification, while the pinacol boronate moiety enables reliable coupling with aryl halides and pseudohalides under standard catalytic conditions. This compound functions as a key intermediate in the synthesis of biaryl scaffolds and complex heterocycles relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.79
  • LogP   3.7456
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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