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Structure of 334951-61-0
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Nintedanib Impurity features a (Z)-configured enol ether linkage and a piperazinyl-modified aryl amine moiety, enabling precise structural interrogation in impurity profiling. This indoline derivative bears a methyl ester and a phenyl-substituted imine system, offering enhanced stability under standard analytical conditions.
(Z)-Methyl 3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate serves as a well-characterized impurity associated with nintedanib synthesis. It functions as a key structural analogue in process development and analytical method validation, enabling accurate assessment of reaction completeness and purification efficiency. The compound exhibits bench stability and facilitates targeted monitoring via HPLC-MS due to its distinct chromophore and ionizable piperazine moiety.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: