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CS-W001157 4
Total: USD 88.00

Nintedanib impurity 6

  • CAS No. 334951-61-0

  • Cat. No. CS-0200332
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Nintedanib impurity 6|CS-0200332

Structure of 334951-61-0

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General Information

  • CAS No. 334951-61-0
  • Cat. No. CS-0200332
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₃₁N₅O₄
  • Molecular Weight 525.60
  • Synonym(s) None
  • SMILES O=C(CN1CCNCC1)N(C)C(C=C2)=CC=C2N/C(C3=CC=CC=C3)=C4C5=CC=C(C(OC)=O)C=C5NC/4=O

Description

Nintedanib Impurity features a (Z)-configured enol ether linkage and a piperazinyl-modified aryl amine moiety, enabling precise structural interrogation in impurity profiling. This indoline derivative bears a methyl ester and a phenyl-substituted imine system, offering enhanced stability under standard analytical conditions.

Application

(Z)-Methyl 3-(((4-(N-methyl-2-(piperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate serves as a well-characterized impurity associated with nintedanib synthesis. It functions as a key structural analogue in process development and analytical method validation, enabling accurate assessment of reaction completeness and purification efficiency. The compound exhibits bench stability and facilitates targeted monitoring via HPLC-MS due to its distinct chromophore and ionizable piperazine moiety.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   103.01
  • LogP   3.2737
  • H_Acceptors   7
  • H_Donors   3
  • Rotatable_Bonds   7

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