Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic acid

  • CAS No. 334769-80-1

  • Cat. No. CS-D0422
  • Purity≥97%
  • MDL No.MFCD13185989

*For research and further manufacturing use only, not for direct human use.

(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic acid|CS-D0422

Structure of 334769-80-1

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 334769-80-1
  • Cat. No. CS-D0422
  • Purity ≥97%
  • MDL No. MFCD13185989
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₄
  • Molecular Weight 229.27
  • Synonym(s) (2S,5S)-1-(Tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid
  • SMILES O=C([C@H]1N(C(OC(C)(C)C)=O)[C@@H](C)CC1)O

Description

(2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic acid is a stereochemically defined pyrrolidine derivative featuring a Boc-protected amine and a methyl group at the 5-position. This configuration enhances conformational rigidity, enabling its use in asymmetric synthesis and peptide mimetics. The bench-stable, moisture-tolerant structure simplifies handling in multistep transformations.

Application

(2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptidomimetics. The Boc-protected amine and carboxylic acid functionalities enable straightforward coupling reactions, while the 5-methyl substituent enhances conformational rigidity. This stable, bench-ready intermediate facilitates efficient access to complex scaffolds in medicinal chemistry campaigns.

Synthesis

  • Route1
    • 1-(Tert-butyl) 2-ethyl (2S,5S)-5-methylpyrrolidine-1,2-dicarboxylate|CS-0466152
      676560-83-1
    • ~%
    • In-stock
      (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic acid|CS-D0422
      334769-80-1

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      38533-38-9
    • ~%
    • In-stock
      (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic acid|CS-D0422
      334769-80-1

    References

    • Miyazaki, Masaki; Naito, Hiroyuki; Sugimoto, Yuuichi; Yoshida, Keisuke; Kawato, Haruko; Okayama, Tooru; Shimizu, Hironari; Miyazaki, Masaya; Kitagawa, Mayumi; Seki, Takahiko; Fukutake, Setsuko; Shiose, Yoshinobu; Aonuma, Masashi; Soga, Tsunehiko Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4319 - 4331
  • Route3
    • null|null
      896733-29-2
    • ~%
    • In-stock
      (2S,5S)-N-Boc-5-Methylpyrrolidine-2-carboxylic acid|CS-D0422
      334769-80-1

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3520 - 3535

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.859
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 334769-80-1 sigma334769-80-1 manufacturer334769-80-1 price334769-80-1 structure334769-80-1 SDSbuy 334769-80-1334769-80-1 supplier334769-80-1 uses334769-80-1 molecular weightprice of 334769-80-1334769-80-1 chemical name formula of 334769-80-1
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label