Lot numbers can be found on the outside label of a product:
Methyl 3,5-dichloro-4-hydroxybenzoate
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CAS No. 3337-59-5
- Cat. No. CS-0150846
- Purity≥98%
- MDL No.MFCD00016419
*For research and further manufacturing use only, not for direct human use.
Structure of 3337-59-5
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General Information
- CAS No. 3337-59-5
- Cat. No. CS-0150846
- Purity ≥98%
- MDL No. MFCD00016419
- Storage RT, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₆Cl₂O₃
- Molecular Weight 221.04
- Synonym(s) METHYL-4-HYDROXY-3 5-DICHLOROBENZOATE
- SMILES COC(=O)C1=CC(=C(C(=C1)Cl)O)Cl
Description
Tyrphostin inhibit protein tyrosine kinase and block the EGF-dependent autophosphorylation of the receptor. The inhibitors can bind to the EGF receptor kinase domain with different affinities. It also inhibits PDGFR kinase. Tyrphostin A23 has been used to inhibit agonist-induced GP IIb- IIIa activation in permeabilized platelets and in other studies to block calcium channel currents in vascular smooth muscle cells. . Tyrphostin A23 can also inhibit the internalization of (125)I-transferrin in Heb7a cells.
Application
Methyl 3,5-dichloro-4-hydroxybenzoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted aromatic systems. The ortho-hydroxyl and ester functionalities provide sites for selective derivatization, while the electron-withdrawing dichloro substituents enhance electrophilicity for subsequent coupling reactions. Its bench-stable nature and compatibility with common protecting group strategies facilitate straightforward purification and integration into multi-step syntheses, particularly in the construction of bioactive heterocycles and pharmaceutical intermediates.
Synthesis
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Route1
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In-stock
3336-41-2 - ~95%
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In-stock
3337-59-5
References
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Dawson, Marcia J.; Fontana, Joseph A.; Zhang, Xiao-kun; Leid, Mark; Jong, Ling; Hobbs, Peter D. Patent: US2003/176506 A1, 2003 ;
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Route2
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67-56-1 -
In-stock
3336-41-2
- ~%
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In-stock
3337-59-5
References
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Justus Liebigs Annalen der Chemie, , vol. 261, p. 254 Gazzetta Chimica Italiana, , vol. 29 II, p. 39
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Route3
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In-stock
99-76-3 - ~%
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In-stock
3337-59-5
References
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Gazzetta Chimica Italiana, , vol. 29 I, p. 387,388
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.53
- LogP 2.4856
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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