Ethyl L-prolinate hydrochloride

Name: Ethyl L-prolinate hydrochloride
Brand: ChemScene
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CAS No. 33305-75-8
Cat. No. CS-0120026
Molecule weight179.64
Purity≥97%
MDL No.MFCD00191004

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Ethyl L-prolinate hydrochloride|CS-0120026

Structure of 33305-75-8

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General Information

CAS No. 33305-75-8
Cat. No. CS-0120026
Purity ≥97%
MDL No. MFCD00191004
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₄ClNO₂
Molecular Weight 179.64
Synonym(s) (S)-Ethyl pyrrolidine-2-carboxylate hydrochloride
SMILES O=C(OCC)[C@H]1NCCC1.[H]Cl

Description

Ethyl L-prolinate hydrochloride is a bench-stable, moisture-tolerant ester derivative of L-proline, featuring a polar ethyl ester group and a protonated amine. This zwitterionic form enhances solubility in aqueous and polar organic media, enabling seamless integration into peptide coupling sequences and chiral synthesis workflows.

Application

Ethyl L-prolinate hydrochloride serves as a stable, bench-ready chiral building block for peptide and heterocyclic synthesis. Its well-defined stereochemistry and compatibility with standard coupling conditions enable reliable incorporation into complex molecular architectures. The hydrochloride salt enhances solubility and simplifies purification, while the ester functionality supports selective transformations in multistep sequences.

Synthesis

Route1
- 64-17-5
- 147-85-3
- ~99%
- In-stock
  
  33305-75-8
References
- Takeuchi; Yamada; Suzuki; Koizumi Tetrahedron, 1996 , vol. 52, # 1 p. 225 - 232

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 38.33
LogP 0.7233
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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Ethyl L-prolinate hydrochloride

CAS No. 33305-75-8

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