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Structure of 33252-26-5
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4-(Tert-butyl)pyridin-2-amine features a sterically hindered tert-butyl group that enhances solubility and stability while the pyridine nitrogen provides a strong ligating site. This combination enables efficient coordination in transition metal catalysis and facilitates modular synthesis in pharmaceutical intermediates.
4-(Tert-butyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its pyridine nitrogen and primary amine facilitate metal-catalyzed cross-couplings and derivatization, while the bulky tert-butyl group enhances steric protection and metabolic stability. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process-scale applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: