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CS-W001157 4
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Benzofuran-5-ylboronic acid

  • CAS No. 331834-13-0

  • Cat. No. CS-D1098
  • Purity≥98%
  • MDL No.MFCD04038999

*For research and further manufacturing use only, not for direct human use.

Benzofuran-5-ylboronic acid|CS-D1098

Structure of 331834-13-0

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General Information

  • CAS No. 331834-13-0
  • Cat. No. CS-D1098
  • Purity ≥98%
  • MDL No. MFCD04038999
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BO₃
  • Molecular Weight 161.95
  • Synonym(s) benzofuran-5-boronicacid
  • SMILES OB(O)C1=CC=C(OC=C2)C2=C1

Description

Benzofuran-5-ylboronic acid is a bench-stable boronic acid featuring a fused heterocyclic core that enables direct incorporation into Suzuki-Miyaura cross-coupling reactions. The electron-rich benzofuran scaffold enhances reactivity and compatibility with diverse aryl halides under standard conditions. This robust building block facilitates rapid access to biologically relevant scaffolds in medicinal chemistry and materials science.

Application

Benzofuran-5-ylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its stability, ease of handling, and compatibility with diverse functional groups make it ideal for constructing biaryl architectures and complex heterocyclic scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • EP1481965 A1, ; Page 23 ;
  • Route2
    • In-stock
      5-Bromobenzofuran|CS-W003038
      23145-07-5
    • null|null
      5419-55-6
    • null|null
      7732-18-5
    • ~%
    • In-stock
      Benzofuran-5-ylboronic acid|CS-D1098
      331834-13-0

    References

    • WO2012/119046 A2, ; Page/Page column 89 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.6
  • LogP   0.1126
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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