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CS-W001157 4
Total: USD 88.00

2-Chloro-5-(trifluoromethoxy)aniline

  • CAS No. 331-26-0

  • Cat. No. CS-W006784
  • Purity≥98%
  • MDL No.MFCD16658882

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-(trifluoromethoxy)aniline|CS-W006784

Structure of 331-26-0

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General Information

  • CAS No. 331-26-0
  • Cat. No. CS-W006784
  • Purity ≥98%
  • MDL No. MFCD16658882
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅ClF₃NO
  • Molecular Weight 211.57
  • Synonym(s) None
  • SMILES NC1=CC(OC(F)(F)F)=CC=C1Cl

Description

2-Chloro-5-(trifluoromethoxy)aniline features a trifluoromethoxy group that imparts enhanced electron-withdrawal and metabolic stability, while the chloro substituent enables direct electrophilic substitution. This combination delivers high reactivity in coupling reactions and facilitates access to complex heterocyclic architectures under standard conditions.

Application

2-Chloro-5-(trifluoromethoxy)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of both electron-withdrawing chlorine and trifluoromethoxy groups into heterocyclic scaffolds. Its stability under standard reaction conditions facilitates coupling reactions, electrophilic substitutions, and amide formation with predictable regioselectivity. The molecule functions effectively in Suzuki-Miyaura and Ullmann-type transformations, offering reliable access to fluorinated aromatic systems used in pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.8208
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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