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CS-W001157 4
Total: USD 88.00

6-Bromo-1H-indene

  • CAS No. 33065-61-1

  • Cat. No. CS-W019162
  • Purity95% (stabilized with TBC)
  • MDL No.MFCD08234616

*For research and further manufacturing use only, not for direct human use.

6-Bromo-1H-indene|CS-W019162

Structure of 33065-61-1

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General Information

  • CAS No. 33065-61-1
  • Cat. No. CS-W019162
  • Purity 95% (stabilized with TBC)
  • MDL No. MFCD08234616
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇Br
  • Molecular Weight 195.06
  • Synonym(s) Bromo-1H-indene
  • SMILES BrC1=CC2=C(C=C1)C=CC2

Description

6-Bromo-1H-indene is a brominated indene derivative featuring a reactive vinyl group and a bromine substituent at the 6-position. This structure enables facile functionalization in cross-coupling reactions, serving as a valuable intermediate in synthetic organic chemistry. The molecule exhibits enhanced stability under standard conditions and integrates readily into complex molecular architectures.

Application

6-Bromo-1H-indene serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo group and conjugated indene framework. The molecule exhibits good bench stability and facilitates efficient functionalization at the olefinic position, making it valuable for constructing complex heterocycles and pharmaceutical scaffolds. Its predictable reactivity profile supports reliable use in standard reaction workflows.

Synthesis

  • Route1

    References

    • JANSSEN PHARMACEUTICA, N.V. Patent: WO2009/67202 A1, 2009 ; Location in patent: Page/Page column 195 ; WO 2009/067202 A1
  • Route2

    References

    • MERCK and CO., INC. Patent: WO2006/52555 A2, 2006 ; Location in patent: Page/Page column 31; 66-67 ;
  • Route3

    References

    • Panarello, Anthony P.; Vassylyev, Oleksiy; Khinast, Johannes G. Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1353 - 1356

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.0184
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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