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CS-W001157 4
Total: USD 88.00

L-Alanyl-L-leucine

  • CAS No. 3303-34-2

  • Cat. No. CS-W020828
  • Purity≥98%
  • MDL No.MFCD00065106

*For research and further manufacturing use only, not for direct human use.

L-Alanyl-L-leucine|CS-W020828

Structure of 3303-34-2

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General Information

  • CAS No. 3303-34-2
  • Cat. No. CS-W020828
  • Purity ≥98%
  • MDL No. MFCD00065106
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈N₂O₃
  • Molecular Weight 202.25
  • Synonym(s) H-Ala-Leu-OH
  • SMILES CC(C)C[C@@H](C(O)=O)NC([C@H](C)N)=O

Description

L-Alanyl-L-leucine is a dipeptide featuring a stable amide linkage between L-alanine and L-leucine, offering enhanced solubility and metabolic stability compared to free amino acids. This structural motif enables efficient incorporation into peptide synthesis workflows, particularly in the development of bioactive sequences requiring protease resistance and controlled degradation kinetics.

Application

L-Alanyl-L-leucine serves as a well-defined dipeptide building block for peptide synthesis, offering robust bench stability and straightforward purification. Its orthogonal side-chain functionality enables selective derivatization in multi-step sequences, while the N-terminal amine and C-terminal carboxylate support standard coupling protocols. Functions effectively in solid-phase and solution-phase methodologies for peptide library construction and fragment-based drug discovery.

Synthesis

  • Route1
    • L-Alanine Enalapril  Impurity|CS-0229434
      56-41-7
    • L-Leucine, 99%|CS-1269060
      61-90-5
    • ~%
    • In-stock
      L-Alanyl-L-leucine|CS-W020828
      3303-34-2

    References

    • EP1941896 A1, ; Page/Page column 6 ;
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 107, # 14 p. 4249 - 4252
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 107, # 14 p. 4249 - 4252

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   92.42
  • LogP   -0.0509
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   5

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