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CS-W001157 4
Total: USD 88.00

1,2,3,4-Tetrahydroisoquinolin-8-ol

  • CAS No. 32999-37-4

  • Cat. No. CS-0138849
  • Purity≥95%
  • MDL No.MFCD11506139

*For research and further manufacturing use only, not for direct human use.

1,2,3,4-Tetrahydroisoquinolin-8-ol|CS-0138849

Structure of 32999-37-4

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General Information

  • CAS No. 32999-37-4
  • Cat. No. CS-0138849
  • Purity ≥95%
  • MDL No. MFCD11506139
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO
  • Molecular Weight 149.19
  • Synonym(s) 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-8-OL
  • SMILES OC1=CC=CC2=C1CNCC2

Description

This tetrahydroisoquinolin-8-ol features a fused heterocyclic scaffold with a phenolic hydroxyl group at the 8-position, conferring enhanced solubility and hydrogen-bonding capacity. The saturated ring system imparts metabolic stability and favorable pharmacokinetic properties, making it a valuable scaffold for medicinal chemistry applications involving CNS-targeted therapeutics and alkaloid-based synthesis.

Application

1,2,3,4-Tetrahydroisoquinolin-8-ol serves as a versatile scaffold for medicinal chemistry and natural product synthesis, featuring a readily functionalizable phenolic hydroxyl group and a saturated isoquinoline core. Its stability under standard reaction conditions enables efficient derivatization via etherification, esterification, or metal-catalyzed coupling reactions. The compound functions as a key intermediate in the construction of alkaloid derivatives and exhibits favorable solubility and purification characteristics for high-throughput screening applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   1.0379
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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