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5-Methoxyl-2-tetralone

  • CAS No. 32940-15-1

  • Cat. No. CS-B0110
  • Purity≥95%
  • MDL No.MFCD00064958

*For research and further manufacturing use only, not for direct human use.

5-Methoxyl-2-tetralone|CS-B0110

Structure of 32940-15-1

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General Information

  • CAS No. 32940-15-1
  • Cat. No. CS-B0110
  • Purity ≥95%
  • MDL No. MFCD00064958
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₂
  • Molecular Weight None
  • Synonym(s) 5-methoxy-3,4-dihydronaphthalen-2(1H)-one
  • SMILES O=C1CCC(C(OC)=CC=C2)=C2C1

Description

5-Methoxyl-2-tetralone features a fused bicyclic core with a ketone at position 2 and a methoxy group at C5, offering enhanced solubility and stability. This electron-rich scaffold facilitates efficient coupling reactions and serves as a key intermediate in the synthesis of bioactive compounds, particularly in medicinal chemistry applications involving heterocyclic ring systems.

Application

5-Methoxyl-2-tetralone serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted tetralin scaffolds. Its conjugated enone system facilitates Michael additions, catalytic hydrogenations, and electrophilic functionalizations under mild conditions. The methoxy group enhances solubility and provides a handle for further derivatization, while the ketone functionality supports reductive amination and Grignard reactions. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses targeting bioactive molecules and pharmaceutical intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.753
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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